Chemotherapeutic Strategy Treatment of Brain Metastases from Lung Cancer through Antiangiogenesis Mechanism.

In some cases brain metastases arise from non-small cell lung cancer, and chemotherapy has been used for long periods in the treatment of these cases, but its effectiveness has not been proven due to its weak effect in addition to its deadly toxic properties. Therefore, there was a need to search for appropriate therapeutic means for these cases, so work was done on vascular endothelial growth factor, which has an important role in the development of the disease. Where it was used against those blood vessels, either alone or combined with drugs toxic to cancer cells. One of the most important enzymes that play an important role in the formation of brain edema is cyclooxygenase (COX) -2, through its role in the production of PGE2 production. Therefore, COX-2 inhibitors are used in the treatment of brain tumors. In this report, a case will be presented of a patient with lung cancer, in addition to having brain metastases, who was treated with radiotherapy and chemotherapy. Gemcitabine, thalidomide, and celceoxib were added to the treatment protocol and by examining the patient it was found that he had completely recovered from brain metastases. Therefore, this protocol is recommended in the treatment of these patients. [ABSTRACT FROM AUTHOR]