First Affiliated Hospital of Anhui Medical University Researchers Have Published New Data on Gastric Cancer (Circular RNA hsa_circ_0051246 acts as a microRNA-375 sponge to promote the progression of gastric cancer stem cells via YAP1).

A recent study conducted by researchers at the First Affiliated Hospital of Anhui Medical University in China has investigated the role of circular RNA hsa_circ_0051246 in promoting the progression of gastric cancer stem cells. The study found that circ_0051246 acts as a sponge for microRNA-375, inhibiting its biological function in gastric cancer cells. The researchers also discovered that the oncoprotein Yes-associated protein 1 (YAP1) is targeted by miR-375 and can be inactivated via the Hippo tumor suppressor pathway. The study provides insights into the molecular mechanisms of gastric cancer stem cells and highlights the potential of circ_0051246-miR-375-YAP1 axis activation in gastric cancer progression. [Extracted from the article]