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Impact of influenza immunity on the mortality among older adults hospitalized with COVID-19: a retrospective cohort study.
- Source :
- Clinical & Experimental Medicine; Dec2023, Vol. 23 Issue 8, p4955-4965, 11p
- Publication Year :
- 2023
-
Abstract
- It has been suggested that the outcomes of coronavirus disease 2019 (COVID-19) are better in individuals having recently received an influenza vaccine than in non-vaccinated individuals. We hypothesized that this association depends on the humoral responses against influenza viruses. We aim to assess the relationship between the humoral immunity against influenza and the 3-month all-cause mortality among hospitalized older patients with COVID-19. We performed an exploratory retrospective study of older patients (aged 65 and over) hospitalized for confirmed COVID-19 between November 2020 and June 2021. Previous humoral responses to influenza viruses were assessed using a hemagglutination inhibition assay on routinely collected blood samples. The study's primary outcome was the 3-month all-cause mortality, and the secondary outcomes were severe COVID-19 (oxygen requirement ≥ 6 L/min or ventilatory support) and complications (kidney or heart failure, thrombosis and bacterial infection). In the cohort of 95 patients with COVID-19, immunity against influenza vaccine subtypes/lineages was not significantly associated with 3-month all-cause mortality, with an OR [95%CI] of 0.22 [0.02–1.95] (p = 0.174) for the H1N1pdm09 subtype, 0.21 [0.03–1.24] (p = 0.081) for A/Hong Kong/2671/2019 H3N2 subtype, 1.98 [0.51–8.24] (p = 0.329) for the B/Victoria lineage, and 1.82 [0.40–8.45] (p = 0.437) for the B/Yamagata lineage. Immunity against influenza vaccine subtypes/lineages was also not significantly associated with severity and complication. Immunity against influenza subtypes/lineages included in the 2020–2021 vaccine was not associated with a lower 3-month all-cause mortality among COVID-19 hospitalized patients. Trial registration: The study was approved by a hospital committee with competency for research not requiring approval by an institutional review board (Tours University Medical Center, Tours, France: reference: 2021_015). All patients give the informed consent. [ABSTRACT FROM AUTHOR]
- Subjects :
- INFLUENZA
OLDER people
COVID-19
INFORMED consent (Medical law)
COHORT analysis
Subjects
Details
- Language :
- English
- ISSN :
- 15918890
- Volume :
- 23
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Clinical & Experimental Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 174266761
- Full Text :
- https://doi.org/10.1007/s10238-023-01203-0