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Myelin water imaging at 0.55 T using a multigradient‐echo sequence.
- Source :
- Magnetic Resonance in Medicine; Mar2024, Vol. 91 Issue 3, p1043-1056, 14p
- Publication Year :
- 2024
-
Abstract
- Purpose: To investigate the prospects of a multigradient‐echo (mGRE) acquisition for in vivo myelin water imaging at 0.55 T. Methods: Scans were performed on the brain of four healthy volunteers at 0.55 and 3 T, using a 3D mGRE sequence. The myelin water fraction (MWF) was calculated for both field strengths using a nonnegative least squares (NNLS) algorithm, implemented in the qMRLab suite. The quality of these maps as well as single‐voxel fits were compared visually for 0.55 and 3 T. Results: The obtained MWF values at 0.55 T are consistent with previously reported ones at higher field strengths. The MWF maps are a considerable improvement over the ones at 3 T. Example fits show that 0.55 T data is better described by an exponential model than 3 T data, making the assumed multi‐exponential model of the NNLS algorithm more accurate. Conclusion: This first assessment shows that mGRE myelin water imaging at 0.55 T is feasible and has the potential to yield better results than at higher fields. [ABSTRACT FROM AUTHOR]
- Subjects :
- MYELIN
VOLUNTEERS
ALGORITHMS
VOLUNTEER service
Subjects
Details
- Language :
- English
- ISSN :
- 07403194
- Volume :
- 91
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Magnetic Resonance in Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 174346106
- Full Text :
- https://doi.org/10.1002/mrm.29949