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The effect of adding L-Carnitine to the GnRH-antagonist protocol on assisted reproductive technology outcome in women with polycystic ovarian syndrome: a randomized clinical trial.

Authors :
Sheida, Arezoo
Davar, Robab
Tabibnejad, Nasim
Eftekhar, Maryam
Source :
Gynecological Endocrinology; December 2023, Vol. 39 Issue 1, p1-5, 5p
Publication Year :
2023

Abstract

This study aimed to investigate the effect of adding L-Carnitine to the gonadotropins on ART outcome in frozen-thawed embryo transfer cycles among PCOS women. In this randomized clinical trial, 83 patients with PCOS were randomized to either L-Carnitine supplemented (n = 42) or control (n = 41) groups. The L-Carnitine group was given 3000 mg of oral L-Carnitine daily until the final day of ovulation. The numbers of metaphase II (MII) oocytes, 2-pronuclears (2PNs), oocyte maturity rate, fertilization rate, fertilization proportion as well as implantation, chemical and clinical pregnancy rates were compared between the two groups. Even though the duration of stimulation and endometrial thickness were comparable between groups (p >.05), serum estradiol level on the day of oocyte triggering, was significantly higher in the L-Carnitine group compared to the control group (p <.05). In contrast, the number of retrieved and MII oocytes as well as the number of 2PNs and obtained embryos were similar between groups (p >.05). Moreover, oocyte maturity rate (0.85 ± 0.38 vs. 1.02 ± 0.90), fertilization proportion (0.62 ± 0.44 vs. 0.80 ± 0.86), fertilization rate (0.70 ± 0.22 vs. 0.76 ± 0.19) along with implantation rate (18.1 vs. 13.7%), chemical (26.8 vs. 30.7%) and clinical (24.3 vs. 25.6%) pregnancy rates, were all comparable between L-Carnitine and control groups respectively (p >.05). Our result showed that oral L-Carnitine administration during induction of ovulation among PCOS women could not improve laboratory and pregnancy outcome. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09513590
Volume :
39
Issue :
1
Database :
Complementary Index
Journal :
Gynecological Endocrinology
Publication Type :
Academic Journal
Accession number :
174390599
Full Text :
https://doi.org/10.1080/09513590.2021.1878135