Back to Search Start Over

Characteristics of high‐risk HPV infection in women with vaginal intraepithelial neoplasia in Beijing, China.

Characteristics of high‐risk HPV infection in women with vaginal intraepithelial neoplasia in Beijing, China.

Authors :
Ye, Yanqing
Li, Mingxia
Yang, Wen
Xu, Jia
Wang, Xueqi
Ma, Yaqi
Wu, Di
Meng, Yuanguang
Source :
Journal of Medical Virology; Dec2023, Vol. 95 Issue 12, p1-9, 9p
Publication Year :
2023

Abstract

We evaluated the characteristics of high‐risk human papillomavirus (Hr‐HPV) infection in different grades of vaginal intraepithelial neoplasia (VaIN). 7469 participants were involved in this study, of which 601 were diagnosed with VaIN, including single vaginal intraepithelial neoplasia (s‐VaIN, n = 369) and VaIN+CIN (n = 232), 3414 with single cervical intraepithelial neoplasia (s‐CIN), 3446 with cervicitis or vaginitis and 8 with vaginal cancer. We got those results. First, the most popular HPV genotypes in VaIN were HPV16, 52, 58, 51, and 56. Second, our study showed that higher parity and older age were risk factors for VaIN3 (p < 0.005). Third, the median Hr‐HPV load of VaIN+CIN (725) was higher than that of s‐CIN (258) (p = 0.027), and the median Hr‐HPV load increased with the grade of VaIN. In addition, the risk of VaIN3 was higher in women with single HPV16 infections (p = 0.01), but those with multiple HPV16 infections faced a higher risk of s‐VaIN (p = 0.003) or VaIN+CIN (p = 0.01). Our results suggested that women with higher gravidity and parity, higher Hr‐HPV load, multiple HPV16 infections, and perimenopause or menopause status faced a higher risk for VaIN, while those with higher parity, single HPV16 infections, and menopause status are more prone to VaIN3. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01466615
Volume :
95
Issue :
12
Database :
Complementary Index
Journal :
Journal of Medical Virology
Publication Type :
Academic Journal
Accession number :
174472802
Full Text :
https://doi.org/10.1002/jmv.29267