Shanghai Jiao Tong University School of Medicine Researchers Detail New Studies and Findings in the Area of Osteoporosis (Ameliorative effects on osteoporosis of small extracellular vesicles derived from bone marrow mesenchymal stem cells).

A study conducted by researchers at Shanghai Jiao Tong University School of Medicine in China investigated the effects of small extracellular vesicles (sEVs) derived from human bone marrow mesenchymal stem cells (BMSCs) on osteoclast differentiation and macrophage polarization in mice with osteoporosis. The sEVs were found to inhibit osteoclast formation and decrease the expression of osteoclast marker genes. They also inhibited macrophage polarization to the M1 phenotype and induced polarization to the M2 phenotype. Additionally, the sEVs delayed bone loss in osteoporosis mice by promoting the polarization of M2 type macrophages. [Extracted from the article]