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Therapeutic drug monitoring and virological response at week 48 in a cohort of HIV‐1‐infected patients switching to dolutegravir/rilpivirine dual maintenance therapy (ANRS‐MIE‐BIRIDER study).

Authors :
Lemaitre, Florian
Lagoutte‐Renosi, Jennifer
Gagnieu, Marie‐Claude
Parant, François
Venisse, Nicolas
Grégoire, Matthieu
Bouchet, Stéphane
Garraffo, Rodolphe
Lê, Minh P.
Muret, Patrice
Comets, Emmanuelle
Solas, Caroline
Peytavin, Gilles
Chirouze, Catherine
Hustache‐Mathieu, Laurent
Gendrin, Vincent
Drobatcheff‐Thiebaut, Marie‐Christine
Foltzer, Adeline
Obry‐Roguet, Véronique
Brégigeon, Sylvie
Source :
British Journal of Clinical Pharmacology; Jan2024, Vol. 90 Issue 1, p264-273, 10p
Publication Year :
2024

Abstract

Aims: Dolutegravir (DTG) and rilpivirine (RPV) dual therapy is now recommended as a switch option in virologically suppressed HIV patients. Literature suggests that virological failure with dual therapy could possibly relate to subtherapeutic drug concentrations. In this study, we aimed at describing the DTG and RPV trough plasma concentrations (Cmin) and plasma HIV‐1 RNA viral load (VL) during maintenance dual therapy. Methods: We performed a retrospective analysis of DTG and RPV therapeutic drug monitoring in people living with HIV/AIDS (PLWHA) with dual therapy in 9 French centres. DTG and RPV trough plasma concentrations were estimated using a Bayesian approach to predict Cmin. The relationship between the pharmacokinetics of DTG and RPV and VL > 50 copies (cp)/mL was explored using joint nonlinear mixed models. The frequency of subtherapeutic threshold (DTG Cmin below 640 ng/mL and RPV Cmin below 50 ng/mL) were compared between PLWHA presenting VL > 50 cp/mL or not during the study. Results: At baseline, 209 PLWHA were enrolled in the study. At week 48, 19 people living with HIV/AIDS (9.1%) discontinued their treatment and 15 PLWHA (7.1%) exhibited VL > 50 cp/mL. Six PLWHA out of 15 (40.0%) with VL > 50 cp/mL during the follow‐up had at least 1 Cmin below the respective thresholds while only 26/194 patients (13.4%) without virological replication had at least 1 concentration below the threshold (P =.015). Conclusion: A majority of PLWHA receiving DTG/RPV maintenance dual therapy demonstrated VL < 50 cp/mL but virological replication was more frequent in people living with HIV/AIDS with subtherapeutic Cmin. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03065251
Volume :
90
Issue :
1
Database :
Complementary Index
Journal :
British Journal of Clinical Pharmacology
Publication Type :
Academic Journal
Accession number :
174515124
Full Text :
https://doi.org/10.1111/bcp.15890