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Immunomodulatory effects of epiphytic Loranthus micranthus leaf extracts collected from two host plants: Psidium guajava and Parkia biglobosa.
- Source :
- BMC Complementary Medicine & Therapies; 1/2/2024, Vol. 24 Issue 1, p1-12, 12p
- Publication Year :
- 2024
-
Abstract
- Background: Immunological abnormalities are implicated in the pathogenesis of many chronic diseases. Due to the drug-related adverse effects of currently available orthodox immunomodulators, natural immunomodulators are being looked upon as potential agents to replace them in therapeutic regimens. This research aimed to investigate the immunomodulatory potential of L. micranthus extracts epiphytic on Psidium guajava (LMPGE) and Parkia biglobosa (LMPBE). Methods: Phytochemical screening and acute toxicity testing were carried out to identify the phytoconstituents and safety profiles of the extracts. The extracts' innate and adaptive immunomodulatory potentials were determined in experimental animals using in vivo leucocyte mobilization, delayed-type hypersensitivity (DTH) response, hemagglutination antibody titre, and cyclophosphamide-induced myelosuppression models. Levamisole was used as the standard drug throughout the study. Results: Compared to LMPBE, LMPGE contained significantly (p < 0.05) more tannins, cyanogenic glycosides, saponins, reducing sugars, glycosides, flavonoids, and alkaloids. Furthermore, the groups treated with the extracts had a significant (p < 0.05) increase in the total number of leucocytes, neutrophils, basophils, and antibody titers relative to the untreated control. In the same way, the treatment raised TLC in cyclophosphamide-intoxicated rats, with 250 mg/kg b. w. of LMPGE and LMPBE recording 9712.50 ± 178.00 and 8000.00 ± 105.00 × 109 /L, respectively, compared to 3425.00 ± 2 5.00 × 109 /L in the untreated group. Overall, LMPGE was more effective. Conclusions: The findings from this study suggest that L. micranthus epiphytic in Psidium guajava and Parkia biglobosa has possible immune stimulating potential. [ABSTRACT FROM AUTHOR]
- Subjects :
- PHYTOTHERAPY
NATURAL immunity
HEMAGGLUTINATION tests
IN vivo studies
IMMUNOGLOBULINS
BASOPHILS
FLAVONOIDS
TERPENES
ANIMAL experimentation
ONE-way analysis of variance
ALKALOIDS
STEROIDS
IMMUNE system
QUANTITATIVE research
TANNINS
GLYCOSIDES
GUMS & resins
RATS
QUALITATIVE research
T-test (Statistics)
PHYTOCHEMICALS
IMIDAZOLES
NEUTROPHILS
DESCRIPTIVE statistics
CYCLOPHOSPHAMIDE
LEAVES
TOXICITY testing
CARBOHYDRATES
PLANT extracts
DATA analysis software
ALLERGIES
ANTHELMINTICS
CELLULAR immunity
BONE marrow diseases
GUAVA
MICE
Subjects
Details
- Language :
- English
- ISSN :
- 26627671
- Volume :
- 24
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- BMC Complementary Medicine & Therapies
- Publication Type :
- Academic Journal
- Accession number :
- 174558989
- Full Text :
- https://doi.org/10.1186/s12906-023-04282-4