Research from University of Texas Austin in the Area of Endometrial Cancer Described (Inhibition of DHODH Enhances Replication-Associated Genomic Instability and Promotes Sensitivity in Endometrial Cancer).

A recent report from the University of Texas Austin highlights the prevalence of endometrial carcinoma (EC) as the most common gynecological malignancy in the United States. The study focuses on the role of dihydroorotate dehydrogenase (DHODH) in cancer cell DNA replication and its impact on treatment response. The research reveals that endometrial tumors with overexpression of DHODH are associated with a high mutation count and chromosomal instability. Inhibition of DHODH in endometrial cancer cell lines induces replication-associated DNA damage and hinders replication fork progression, making DHODH a potential target for enhancing cytotoxicity in high-grade endometrial tumors. [Extracted from the article]