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Effect of castalagin against HSV-1 infection in newborn mice.
- Source :
- Natural Product Research; 2023, Vol. 37 Issue 24, p4156-4161, 6p
- Publication Year :
- 2023
-
Abstract
- We tested in vivo anti-herpetic effect of castalagin, an ellagitannin compound, extracted from pedunculate oak (Quercus robur). Previous investigations found that castalagin possesses a strong inhibitory effect in vitro against HSV-1/2 equal to acyclovir (ACV). It is also effective against ACV-resistant mutants and shows a synergistic effect with ACV. We study castalagin's activity towards HSV-1 infection in newborn mice. Acute toxicity determination in mice showed LD<subscript>50</subscript> value of 295mg/kg. Prolonged toxicity was also constructed. Castalagin manifested a marked activity against HSV-1 (LD<subscript>90</subscript>/0.02 ml) administered in 7-day course at 0.02ml s.c. doses of 7.5 or 10 mg/kg (PI 57-58%). ACV course demonstrated a marked activity at 20 mg/kg. The selectivity ratio LD<subscript>50</subscript>/ED<subscript>50</subscript> (295/7.5) could be accepted as ≥ 33. [ABSTRACT FROM AUTHOR]
- Subjects :
- HUMAN herpesvirus 1
ENGLISH oak
Subjects
Details
- Language :
- English
- ISSN :
- 14786419
- Volume :
- 37
- Issue :
- 24
- Database :
- Complementary Index
- Journal :
- Natural Product Research
- Publication Type :
- Academic Journal
- Accession number :
- 174701571
- Full Text :
- https://doi.org/10.1080/14786419.2023.2173191