National Autonomous University of Mexico (UNAM) Reports Findings in Salmonella typhimurium (Interactions between the AraC/XylS-like transcriptional activator InvF of Salmonella Typhimurium, the RNA polymerase alpha subunit and the chaperone SicA).

A report from the National Autonomous University of Mexico (UNAM) discusses the findings of a study on Salmonella typhimurium, a bacterium that causes gastroenteritis and systemic infections in humans. The study focuses on the expression of a type III secretion system (T3SS) and effector proteins encoded in the Salmonella pathogenicity island-1 (SPI-1), which are crucial for the bacterium's virulence. The research confirms the interaction between the transcriptional regulator InvF and the chaperone SicA, as well as their interaction with the RNA polymerase alpha subunit. This study also reveals the first interaction between the chaperone SicA and the RNA polymerase. [Extracted from the article]