Dependency, Capacity, and Agency: Austerity and Leadership Failures in Brazil's Homegrown COVID-19 Vaccine Efforts.

Differential access to life-saving COVID-19 vaccines reveals the inequitable distribution of wealth and power in the global system. While several countries have developed homegrown vaccines to avoid being priced out of markets dominated by transnational drug companies, Brazil—a country with a significant research and pharmaceutical base—lagged behind those of other middle-income countries. Why? This paper blends insights from dependency theory and the theory of global capitalism to demonstrate how political coalitions, leadership, and normative frameworks negatively affect state capacity and technological development. First, austerity in public investment in research, development, and innovation prior to and during the pandemic limited the amount of resources necessary to create homegrown vaccine candidates. Second, political leadership informed by science denialism did not prioritize the development of vaccines and even discouraged their use. The analysis of vaccine development in Brazil reveals that having a pharmaceutical base and strong leadership committed to scientific principles and backed by a political coalition seeking to expand social democratic rights play a vital role in developing treatments and responding to health crises. [ABSTRACT FROM AUTHOR]