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Targeting TIGIT for cancer immunotherapy: recent advances and future directions.

Authors :
Zhang, Peng
Liu, Xinyuan
Gu, Zhuoyu
Jiang, Zhongxing
Zhao, Song
Song, Yongping
Yu, Jifeng
Source :
Biomarker Research; 1/16/2024, Vol. 12 Issue 1, p1-23, 23p
Publication Year :
2024

Abstract

As a newly identified checkpoint, T cell immunoreceptor with immunoglobulin and tyrosine-based inhibitory motif (ITIM) domain (TIGIT) is highly expressed on CD4<superscript>+</superscript> T cells, CD8<superscript>+</superscript> T cells, natural killer (NK) cells, regulatory T cells (Tregs), and tumor-infiltrating lymphocytes (TILs). TIGIT has been associated with NK cell exhaustion in vivo and in individuals with various cancers. It not only modulates NK cell survival but also mediates T cell exhaustion. As the primary ligand of TIGIT in humans, CD155 may be the main target for immunotherapy due to its interaction with TIGIT. It has been found that the anti-programmed cell death protein 1 (PD-1) treatment response in cancer immunotherapy is correlated with CD155 but not TIGIT. Anti-TIGIT alone and in combination with anti-PD-1 agents have been tested for cancer immunotherapy. Although two clinical studies on advanced lung cancer had positive results, the TIGIT-targeted antibody, tiragolumab, recently failed in two new trials. In this review, we highlight the current developments on TIGIT for cancer immunotherapy and discuss the characteristics and functions of TIGIT. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20507771
Volume :
12
Issue :
1
Database :
Complementary Index
Journal :
Biomarker Research
Publication Type :
Academic Journal
Accession number :
174817578
Full Text :
https://doi.org/10.1186/s40364-023-00543-z