A REVIEW ON SURVIVAL STRATEGIES OF LEISHMANIA WITHIN MACROPHAGES.

Leishmaniasis is a widespread disease transmitted by vectors and characterized by complex interactions between the host's immune system and the parasite. Leishmania, a protozoan parasite is the causative agent of the disease. This parasite has the ability to infect and thrive inside macrophages, which are the body's primary fighting cells. This review paper explores the various strategies employed by Leishmania to overcome the defensive mechanisms of macrophages and survive within the hostile intracellular environment. The study delves into the molecular mechanisms used by Leishmania to influence the process of phagolysosome maturation, evade immunological detection and exploit signaling pathways within macrophages. Furthermore, the paper underscores the significant role of host genetics and immune response variability in influencing the outcome of this host-pathogen interaction. A thorough understanding of the intricate interactions between Leishmania parasites and macrophages is essential in developing innovative therapeutic approaches to treat Leishmania infection. [ABSTRACT FROM AUTHOR]