Investigators from Weill Cornell Medicine Release New Data on Nanoprobes (in Vivo Senescence Imaging Nanoprobe Targets the Associated Reactive Oxygen Species).

Researchers from Weill Cornell Medicine have developed a new nanotechnology called D3, which is a near infrared fluorogenic nanoprobe that can detect and image cellular senescence in real-time. Senescence is a cell-cycle arrest state that can impact aging and cancer. The D3 nanoprobe is activated by highly elevated levels of reactive oxygen species (ROS), which are critical for the induction and maintenance of senescence. When injected into senescent tumor-bearing mice, the D3 nanoprobe accumulates in tumors and its fluorescence signal is turned on specifically by senescence-associated ROS. This groundbreaking design provides a powerful imaging tool to identify and assess cellular senescence in living organisms. [Extracted from the article]