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Post-COVID symptom profiles and duration in a global convalescent COVID-19 observational cohort: Correlations with demographics, medical history, acute COVID-19 severity and global region.
- Source :
- Journal of Global Health; 2023, Vol. 13, p1-13, 13p
- Publication Year :
- 2023
-
Abstract
- Background Post-COVID conditions are characterised by persistent symptoms that negatively impact quality of life after SARS-CoV-2 diagnosis. While post-COVID risk factors and symptoms have been extensively described in localised regions, especially in the global north, post-COVID conditions remain poorly understood globally. The global, observational cohort study HVTN 405/HPTN 1901 characterises the convalescent course of SARS-CoV-2 infection among adults in North and South America and Africa. Methods We categorised the cohort by infection severity (asymptomatic, symptomatic, no oxygen requirement (NOR), non-invasive oxygen requirement (NIOR), invasive oxygen requirement (IOR)). We applied a regression model to assess correlations of demographics, co-morbidities, disease severity, and concomitant medications with COVID-19 symptom persistence and duration across global regions. Results We enrolled 759 participants from Botswana, Malawi, South Africa, Zambia, Zimbabwe, Peru, and the USA a median of 51 (interquartile range (IQR)=35-66) days post-diagnosis, from May 2020 to March 2021. 53.8% were female, 69.8% were 18-55 years old (median (md)=44 years old, IQR=33-58). Comorbidities included obesity (42.8%), hypertension (24%), diabetes (14%), human immunodeficiency virus (HIV) infection (11.6%) and lung disease (7.5%). 76.2% were symptomatic (NOR=47.4%; NIOR=22.9%; IOR=5.8%). Median COVID-19 duration among symptomatic participants was 20 days (IQR=11-35); 43.4% reported symptoms after COVID-19 resolution, 33.6% reported symptoms ≥30 days, 9.9% reported symptoms ≥60 days. Symptom duration correlated with disease severity (P<0.001, NIOR vs NOR; P=0.003, IOR vs NOR), lung disease (P=0.001), race (P<0.05, non-Hispanic Black vs White), and global region (P<0.001). Prolonged viral shedding correlated with persistent abdominal pain (odds ratio (OR) = 5.51, P < 0.05) and persistent diarrhoea (OR=6.64, P<0.01). Conclusions Post-COVID duration varied with infection severity, race, lung disease, and region. Better understanding post-COVID conditions, including regionally-diverse symptom profiles, may improve clinical assessment and management globally. [ABSTRACT FROM AUTHOR]
- Subjects :
- RESEARCH
KRUSKAL-Wallis Test
COVID-19
SCIENTIFIC observation
CONFIDENCE intervals
POST-acute COVID-19 syndrome
CONVALESCENCE
SEVERITY of illness index
COMPARATIVE studies
DISEASE duration
QUALITY of life
RESEARCH funding
DESCRIPTIVE statistics
CHI-squared test
KAPLAN-Meier estimator
SOCIODEMOGRAPHIC factors
LOGISTIC regression analysis
STATISTICAL correlation
ODDS ratio
DATA analysis software
COVID-19 testing
LONGITUDINAL method
SYMPTOMS
ADULTS
Subjects
Details
- Language :
- English
- ISSN :
- 20472978
- Volume :
- 13
- Database :
- Complementary Index
- Journal :
- Journal of Global Health
- Publication Type :
- Academic Journal
- Accession number :
- 174904719
- Full Text :
- https://doi.org/10.7189/jogh.13.06020