What is the Current Clinical Impact of the CYP2CTG Haplotype?

The article discusses a study on the CYP2C:TG haplotype and its impact on drug metabolism. The study by Zubiaur et al. analyzed the genotype-phenotype relationship of this haplotype in 225 patients receiving different drugs and liver samples from 135 children. The findings of this study contradict previous studies by Bråten et al., which found an increased rate of CYP2C19-dependent metabolism for the CYP2C:TG haplotype. The article highlights the limitations of the study, including the failure to identify functionally important genetic variants within the haplotype and the variability of CYP2C19 activity in different ethnic groups. The authors suggest that further research is needed to replicate the findings on a larger cohort and to identify specific SNPs before the CYP2C:TG haplotype can be used as a biomarker in clinical settings. [Extracted from the article]