Bioactivities and the structural modification of Parthenolide: a review.

Parthenolide, a sesquiterpene lactone derived from Feverfew (Tanacetum parthenium) buds, has attracted significant attention due to its versatile pharmacological potential. It and its derivatives exhibit a range of bioactivities, including antibacterial, anti-leukemia, anticancer, and anti-inflammatory effects. Current research focuses on the structural modifications of parthenolide, exploring how alterations impact its bioactivity. This review aims to provide an overview of recent studies involving parthenolide's structural modifications and their corresponding impact on its biological functionality. By examining these modifications, the intricate relationship between structural changes and enhanced bioactivity is unveiled. The potential implications for drug development and therapeutic strategies are discussed. References have been downloaded via Web of Science, PubMed, Science Direct, and SciFinder Scholar. Publications that report only on the chemical properties of Parthenolide derivatives are beyond the scope of this review and are not included. [ABSTRACT FROM AUTHOR]