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Associations between air pollutants and acute exacerbation of drug-resistant tuberculosis: evidence from a prospective cohort study.
- Source :
- BMC Infectious Diseases; 1/23/2024, Vol. 24 Issue 1, p1-9, 9p
- Publication Year :
- 2024
-
Abstract
- Background: Short-term exposure to air pollution may trigger symptoms of drug-resistant tuberculosis (DR-TB) through stimulating lung tissue, damaging tracheobronchial mucosa, the key anti-mycobacterium T cell immune function, and production and release of inflammatory cytokines. Objective: To investigate the association between acute exacerbations of DR-TB and short-term residential exposure to air pollutants (PM<subscript>10</subscript>, PM<subscript>2.5</subscript>, SO<subscript>2</subscript>, NO<subscript>2</subscript>, CO and O<subscript>3</subscript>) based on a large prospective cohort in Anhui Province, China. Method: Patients were derived from a prospective cohort study of DR-TB in Anhui Province. All DR-TB patients underwent drug-susceptibility testing and prefecture-level reference laboratories confirmed their microbiologies. The case-crossover design was performed to evaluate the association between the risk of acute exacerbations of DR-TB and short-term residential exposure to air pollution. Results: Short-term NO<subscript>2</subscript> exposure was significantly related to an elevated risk of first-time outpatient visit due to acute exacerbations of DR-TB(relative risk:1.159, 95% confidence interval:1.011 ~ 1.329). Stratification analyses revealed that the relationship between the risk of acute exacerbations and NO<subscript>2</subscript> exposure was stronger in the elderly (age ≥ 65) DR-TB patients, and in individuals with a history of TB treatment. Conclusions: NO<subscript>2</subscript> Exposure was significantly associated with an elevated risk of acute exacerbation of DR-TB in Anhui Province, China. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14712334
- Volume :
- 24
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- BMC Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 174971731
- Full Text :
- https://doi.org/10.1186/s12879-024-09011-x