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Design of a tulobuterol patch with improved mechanical properties: effect of transdermal permeation enhancers on the release process of metal ligand-based acrylic pressure-sensitive adhesives.
- Source :
- Drug Delivery & Translational Research; Mar2024, Vol. 14 Issue 3, p802-811, 10p
- Publication Year :
- 2024
-
Abstract
- The aim of this study was to design a tulobuterol (TUL) patch with good penetration behavior and mechanical properties. Particular attention was paid to the effect of transdermal permeation enhancers on the release process of metal ligand-based acrylic pressure-sensitive adhesive (AA-NAT/Fe<superscript>3+</superscript>). The type and dosage of the enhancers were screened by in vitro transdermal penetration in rat skin. The optimized formulation was evaluated in a pharmacokinetic study in rats. Furthermore, the molecular mechanism by which Azone (AZ) improves the release rate of TUL from AA-NAT/Fe<superscript>3+</superscript> was investigated by FT-IR, shear strength test, rheological study, and molecular simulation. As a result, the optimized formula using AA-NAT/Fe<superscript>3+</superscript> showed better mechanical properties compared to commercial products. Meanwhile, the AUC<subscript>0-t</subscript> and C<subscript>max</subscript> of the optimized patch were 1045 ± 89 ng/mL·h and 106.8 ± 28.5 ng/mL, respectively, which were not significantly different from those of the commercial product. In addition, AZ increased the mobility of the pressure-sensitive adhesive (PSA) rather than decreasing the drug-PSA interaction, which was the main factor in enhancing TUL release from the patch. In conclusion, a TUL transdermal drug delivery patch was successfully developed using metal-coordinated PSA, and a reference was provided for the design of metal-coordinated acrylic PSA for transdermal patch delivery applications. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 2190393X
- Volume :
- 14
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Drug Delivery & Translational Research
- Publication Type :
- Academic Journal
- Accession number :
- 175021744
- Full Text :
- https://doi.org/10.1007/s13346-023-01435-3