Genetics and pathologic landscape of lineage switch of acute leukemia during therapy.

The given text is a study published in the Blood Cancer Journal that explores the phenomenon of lineage switch in leukemia, where cells change from one lineage to another. The study includes 33 cases of acute leukemia that underwent lineage switch and provides valuable insights into the clinicopathological features and genetic drivers of this event. The findings suggest that certain risk factors, such as specific genetic abnormalities and the presence of a previous chronic myeloid malignancy, may increase the likelihood of lineage switch. The study emphasizes the importance of early detection and potential benefits of early allogeneic stem cell transplant in these cases, while also highlighting the need for further research to develop preventive and therapeutic strategies. [Extracted from the article]