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Three‐Component 1,4‐Addition through Ugi‐Type Reaction, an Oxidative Dearomatization Strategy.
- Source :
- Asian Journal of Organic Chemistry; Jan2024, Vol. 13 Issue 1, p1-5, 5p
- Publication Year :
- 2024
-
Abstract
- A three‐component 1,4‐addition variant of the Ugi reaction involving carboxylic acids, isocyanides, and cyclic α,β‐unsaturated imines is presented in this study. The cyclic α,β‐unsaturated imines were conveniently prepared through the oxidative dearomatization of N‐substituted anilines. The reaction proceeded successfully to produce a sole diastereomer, and the relative configuration was determined through 2D NMR and X‐ray diffraction analysis. [ABSTRACT FROM AUTHOR]
- Subjects :
- CARBOXYLIC acids
X-ray diffraction
ISOCYANIDES
IMINES
ANILINE
Subjects
Details
- Language :
- English
- ISSN :
- 21935807
- Volume :
- 13
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Asian Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 175056206
- Full Text :
- https://doi.org/10.1002/ajoc.202300502