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Liquid biopsy: A promising tool for driving strategies and predicting failures in patients with classic Hodgkin lymphoma.
- Source :
- Cytopathology; Mar2024, Vol. 35 Issue 2, p182-187, 6p
- Publication Year :
- 2024
-
Abstract
- Classic Hodgkin lymphoma (cHL) consists of a heterogeneous group of haematological disorders that covers undifferentiated B cell neoplasms originating from germinal centre B cells. The HL molecular characterization still represents an ongoing challenge due to the low fraction of tumour Hodgkin and Reed–Sternberg cells mixed with a plethora of non‐tumour haematological cells. In this scenario, next generation sequencing of liquid biopsy samples is emerging as a useful tool in HL patients' management. In this review, we aimed to overview the clinical and methodological topics regarding the implementation of molecular analysis in cHL, focusing on the role of liquid biopsy in diagnosis, follow‐up, and response prediction. [ABSTRACT FROM AUTHOR]
- Subjects :
- HODGKIN'S disease
NUCLEOTIDE sequencing
B cells
BIOPSY
LIQUIDS
Subjects
Details
- Language :
- English
- ISSN :
- 09565507
- Volume :
- 35
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Cytopathology
- Publication Type :
- Academic Journal
- Accession number :
- 175282098
- Full Text :
- https://doi.org/10.1111/cyt.13255