Adiponectin gene polymorphism (rs2241766) in patients with coronary artery disease.

The present study aimed to determine the association between the adiponectin gene (ADIPOQ gene) and coronary artery disease (CAD). Sixty individuals (40 patients and 20 healthy) were comprising in this study. The current results demonstrated significant relationship between TG genotype (22.5% ofCAD patients and 30% of healthy individuals) when compared with TT genotype. GG genotype was less common (12.5% and 15% of patients and control), as comparing with other genotypes. Also, there is no significant differences between GG genotype and TT genotype. There is no significant differences in allel frequencies between CAD patient and control group, while, T allel showed high frequency rate (76.25% and 70% in patients and control group respectively). Five mutations were determined within the studied region of the ADIPOQ gene using mutation surveyor program: 1 (20%) Deletion (g. 15324del C), 2 (40%) Transversion (g.15430G>T), 1 (20%) Transversion (g.15345A>C), 1 (20%) Transversion (g.15454T>A). In conclusion,the current study showed that rs2241766 polymorphisms affect in patients with coronary artery disease. [ABSTRACT FROM AUTHOR]