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Synthesis of Novel Stigmasterol Derivatives with 1,2,3-Triazole Substituent at the C-3 Position and Their Cytotoxicity Toward HeLa, HGC-27, and HEK-293T Cells.
- Source :
- Chemistry of Natural Compounds; Jan2024, Vol. 60 Issue 1, p92-97, 6p
- Publication Year :
- 2024
-
Abstract
- Eight new stigmasterol derivatives possessing 1,2,3-triazoles moiety were synthesized by a 1,3-dipolar cycloaddition reaction. All the compounds were characterized by IR, NMR, and HR-MS. In addition, human cervical cancer cells (HeLa), human gastric cancer cells (HGC-27), and human renal epithelial cells (HEK-293T) were selected to study the antitumor activity of the synthesized compounds. The results demonstrated that compounds 3c and 3d exhibited better inhibitory activity against the tested tumor cell lines. The IC<subscript>50</subscript> value of the inhibitory activity on HeLa was 52.3 μmol·L<superscript>–1</superscript> and 31.4 μmol·L<superscript>–1</superscript>, and 40.6 μmol·L<superscript>–1</superscript> and 44.6 μmol·L<superscript>–1</superscript> for HGC-27, respectively. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00093130
- Volume :
- 60
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Chemistry of Natural Compounds
- Publication Type :
- Academic Journal
- Accession number :
- 175358715
- Full Text :
- https://doi.org/10.1007/s10600-024-04261-2