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Chlorogenic acid attenuates cisplatin-induced ovarian injury in rats.

Authors :
Ayazoglu Demir, Elif
Mentese, Ahmet
Livaoglu, Ayten
Turkmen Alemdar, Nihal
Aliyazicioglu, Yuksel
Demir, Selim
Source :
Drug & Chemical Toxicology; Mar2024, Vol. 47 Issue 2, p213-217, 5p
Publication Year :
2024

Abstract

The aim of this study was to determine the possible therapeutic effect of chlorogenic acid (CGA) on cisplatin (CDDP)-induced ovarian damage in rats. Rats were first exposed to CDDP (5 mg/kg) and then treated CGA (1.5 and 3 mg/kg) for three days. Oxidative stress (OS), inflammation and apoptosis markers were determined using spectrophotometric methods. Ovarian tissues were also evaluated histologically. The levels of OS, inflammation and apoptosis biomarkers increased by CDDP administration (p < 0.05). Treatments with CGA significantly alleviated these markers dose-dependently (p < 0.05). These data reveal that CGA may exert an ovoprotective effect by reducing pro-inflammatory mediators and enhancing antioxidant status in ovarian tissue. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01480545
Volume :
47
Issue :
2
Database :
Complementary Index
Journal :
Drug & Chemical Toxicology
Publication Type :
Academic Journal
Accession number :
175361874
Full Text :
https://doi.org/10.1080/01480545.2023.2172181