Innovative Approaches in the Management of Metastatic Breast Cancer: Managed Care Considerations on the Evolving Role of Targeted Therapy.

Therapies targeting selected genetic mutations and protein expression have dramatically changed the treatment of metastatic breast cancer. Three of these, PARP, PI3K, and CDK 4/6 inhibitors have all been shown to improve progression-free survival and, for some of the agents, overall survival. [ABSTRACT FROM AUTHOR]