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Extensive ecchymotic patch in a patient with chronic lymphocytic leukemia.
- Source :
- International Journal of Dermatology; Mar2024, Vol. 63 Issue 3, p313-315, 3p
- Publication Year :
- 2024
-
Abstract
- A 68-year-old female with a history of chronic lymphocytic leukemia (CLL) presented with an extensive purpuric patch on her left forearm. She had been treated with acalabrutinib for 5 months, and her white blood cell count had risen to 147 K/μl. Laboratory tests showed a platelet count of 152 K/μl and a hematocrit of 34.9%. A punch biopsy revealed vaso-occlusive changes and thrombotic vasculopathy. The patient's purpura resolved 6 weeks after discontinuing acalabrutinib. This case highlights the cutaneous manifestations of acalabrutinib toxicity and the need for monitoring and guidance for patients on BTK inhibitors. [Extracted from the article]
- Subjects :
- CHRONIC lymphocytic leukemia
CHRONIC leukemia
BRUTON tyrosine kinase
Subjects
Details
- Language :
- English
- ISSN :
- 00119059
- Volume :
- 63
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- International Journal of Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 175448167
- Full Text :
- https://doi.org/10.1111/ijd.16801