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Cholesterol paradox in the community-living old adults: is higher better?
- Source :
- Journal of Geriatric Cardiology; Dec2023, Vol. 20 Issue 12, p837-844, 8p
- Publication Year :
- 2023
-
Abstract
- OBJECTIVE: To evaluate the associations of lipid indicators and mortality in Beijing Elderly Comprehensive Health Cohort Study. METHODS: A prospective cohort was conducted based on Beijing Elderly Comprehensive Health Cohort Study with 4499 community older adults. After the baseline survey, the last follow-up was March 31, 2021 with an average 8.13 years of follow-up. Cox proportional hazard model was used to estimate the hazard ratios (HR) with 95% CI for cardiovascular disease (CVD) death and all-cause death in associations with baseline lipid indicators. RESULTS: A total of 4499 participants were recruited, and the mean levels of uric acid, body mass index, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, total cholesterol (TC), triglyceride, and low-density lipoprotein cholesterol (LDL-C) showed an upward trend with the increasing remnant cholesterol (RC) quarters (Ptrend < 0.05), while the downward trend was found in high-density lipoprotein cholesterol (HDL-C). During the total 36,596 person-years follow-up, the CVD mortality and all-cause mortality during an average 8.13 years of follow-up was 3.87% (95% CI: 3.30%-4.43%) and 14.83% (95% CI: 13.79%-15.86%) with 174 CVD death participants and 667 all-cause death participants. After adjusting for confounders, the higher level of TC (HR = 0.854, 95% CI: 0.730-0.997), LDL-C (HR = 0.817, 95% CI: 0.680-0.982) and HDL-C (HR = 0.443, 95% CI: 0.271-0.724) were associated with lower risk of CVD death, and the higher level of HDL-C (HR = 0.637, 95% CI: 0.501-0.810) were associated with lower risk of all-cause death. The higher level of RC (HR = 1.276, 95% CI: 1.010-1.613) increase the risk of CVD death. Compared with the normal lipid group, TC ≥ 6.20 mmol/L group and LDL-C ≥ 4.10 mmol/L group were no longer associated with lower risk of CVD death, while RC ≥ 0.80 mmol/L group was still associated with higher risk of CVD death. In normal lipid group, the higher levels of TC, LDL-C and HDL-C were related with lower CVD death. CONCLUSIONS: In community older adults, higher levels of TC and HDL-C were associated with lower CVD mortality in normal lipid reference range. Higher RC was associated with higher CVD mortality, which may be a better lipid indicator for estimating the CVD death risk in older adults. [ABSTRACT FROM AUTHOR]
- Subjects :
- MORTALITY risk factors
CARDIOVASCULAR disease related mortality
BIOMARKERS
BLOOD pressure
TRIGLYCERIDES
HDL cholesterol
CONFIDENCE intervals
MULTIVARIATE analysis
BLOOD sugar
LDL cholesterol
RISK assessment
SURVEYS
PREPROCEDURAL fasting
COMPARATIVE studies
PEARSON correlation (Statistics)
INDEPENDENT living
QUESTIONNAIRES
DESCRIPTIVE statistics
CHI-squared test
RESEARCH funding
URIC acid
BODY mass index
CHOLESTEROL
LONGITUDINAL method
PROPORTIONAL hazards models
Subjects
Details
- Language :
- English
- ISSN :
- 16715411
- Volume :
- 20
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Journal of Geriatric Cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 175595353
- Full Text :
- https://doi.org/10.26599/1671-5411.2023.12.003