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Behavioral analysis of kainate receptor KO mice and the role of GluK3 subunit in anxiety.

Authors :
Iida, Izumi
Konno, Kohtarou
Natsume, Rie
Abe, Manabu
Watanabe, Masahiko
Sakimura, Kenji
Terunuma, Miho
Source :
Scientific Reports; 2/24/2024, Vol. 14 Issue 1, p1-17, 17p
Publication Year :
2024

Abstract

Kainate receptors (KARs) are one of the ionotropic glutamate receptors in the central nervous system (CNS) comprised of five subunits, GluK1-GluK5. There is a growing interest in the association between KARs and psychiatric disorders, and there have been several studies investigating the behavioral phenotypes of KAR deficient mice, however, the difference in the genetic background has been found to affect phenotype in multiple mouse models of human diseases. Here, we examined GluK1-5 single KO mice in a pure C57BL/6N background and identified that GluK3 KO mice specifically express anxiolytic-like behavior with an alteration in dopamine D2 receptor (D2R)-induced anxiety, and reduced D2R expression in the striatum. Biochemical studies in the mouse cortex confirmed that GluK3 subunits do not assemble with GluK4 and GluK5 subunits, that can be activated by lower concentration of agonists. Overall, we found that GluK3-containing KARs function to express anxiety, which may represent promising anti-anxiety medication targets. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20452322
Volume :
14
Issue :
1
Database :
Complementary Index
Journal :
Scientific Reports
Publication Type :
Academic Journal
Accession number :
175635851
Full Text :
https://doi.org/10.1038/s41598-024-55063-z