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A COX2-targeting cancer-specific fluorescent probe for hydrogen sulfide detection in living cells, Caenorhabditis elegans, and zebrafish.
- Source :
- Analyst; 3/7/2024, Vol. 149 Issue 5, p1489-1495, 7p
- Publication Year :
- 2024
-
Abstract
- A novel cyclooxygenase-2 (COX-2) targeted H<subscript>2</subscript>S-activated cancer-specific fluorescent probe, namely, COX2-H<subscript>2</subscript>S, was designed and synthesized, with naphthalimide as the fluorophore and indomethacin as the targeting group. This H<subscript>2</subscript>S-sensing probe was developed to differentiate tumor cells from normal cells and was tested in living cells, Caenorhabditis elegans (C. elegans), and zebrafish. The probe could successfully be used for imaging endogenous and exogenous H<subscript>2</subscript>S in living cells, demonstrating high sensitivity and specificity and strong anti-interference. COX2-H<subscript>2</subscript>S had the ability to not only discern cancer cells from normal cells but also specifically recognize 9L/lacZ cells from other glioblastoma cells (U87-MG and LN229). It could also be successfully applied for the fluorescent live imaging of H<subscript>2</subscript>S in both C. elegans and zebrafish. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00032654
- Volume :
- 149
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Analyst
- Publication Type :
- Academic Journal
- Accession number :
- 175641490
- Full Text :
- https://doi.org/10.1039/d3an01847d