Back to Search
Start Over
Evaluation of the anti-inflammatory activity of Acacia polyphylla and identification of a new apigenin-3-C- glycosylated type flavonoid.
- Source :
- Natural Product Research; Mar2024, Vol. 38 Issue 6, p1054-1059, 6p
- Publication Year :
- 2024
-
Abstract
- Owing to the potentially harmful adverse effects of current anti-inflammatory drugs, there is a need to identify new alternative substances. Thus, this study aimed to perform a phytochemical analysis of A. polyphylla to identify compounds responsible for its anti-inflammatory activity. Several fractions of the A. polyphylla extract were obtained and evaluated in an ex vivo anti-inflammatory assay using fresh human blood. Among the evaluated fractions, the BH fraction displayed the highest percentage of PGE<subscript>2</subscript> inhibition (74.8%) compared to the reference drugs dexamethasone and indomethacin, demonstrating its excellent potential for anti-inflammatory activity. Astragalin (P1), a known 3-O-glucoside of kaempferol, was isolated from the A. polyphylla extract for the first time. In addition, a new compound (P2) was isolated and identified as the apigenin-3-C-glycosylated flavonoid. Astragalin showed moderate PGE<subscript>2</subscript> activity (48.3%), whereas P2 was not anti-inflammatory. This study contributes to the phytochemical studies of A. polyphylla and confirms its anti-inflammatory potential. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANTI-inflammatory agents
FLAVONOIDS
ACACIA
DEXAMETHASONE
INDOMETHACIN
FLAVONOLS
Subjects
Details
- Language :
- English
- ISSN :
- 14786419
- Volume :
- 38
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Natural Product Research
- Publication Type :
- Academic Journal
- Accession number :
- 175643510
- Full Text :
- https://doi.org/10.1080/14786419.2023.2210256