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Correlation between Histopathological Prognostic Tumor Characteristics and [ 18 F]FDG Uptake in Corresponding Metastases in Newly Diagnosed Metastatic Breast Cancer.
- Source :
- Diagnostics (2075-4418); Feb2024, Vol. 14 Issue 4, p416, 14p
- Publication Year :
- 2024
-
Abstract
- Background: In metastatic breast cancer (MBC), [<superscript>18</superscript>F]fluorodeoxyglucose positron emission tomography/computed tomography ([<superscript>18</superscript>F]FDG-PET/CT) can be used for staging. We evaluated the correlation between BC histopathological characteristics and [<superscript>18</superscript>F]FDG uptake in corresponding metastases. Patients and Methods: Patients with non-rapidly progressive MBC of all subtypes prospectively underwent a baseline histological metastasis biopsy and [<superscript>18</superscript>F]FDG-PET. Biopsies were assessed for estrogen, progesterone, and human epidermal growth factor receptor 2 (ER, PR, HER2); Ki-67; and histological subtype. [<superscript>18</superscript>F]FDG uptake was expressed as maximum standardized uptake value (SUV<subscript>max</subscript>) and results were expressed as geometric means. Results: Of 200 patients, 188 had evaluable metastasis biopsies, and 182 of these contained tumor. HER2 positivity and Ki-67 ≥ 20% were correlated with higher [<superscript>18</superscript>F]FDG uptake (estimated geometric mean SUV<subscript>max</subscript> 10.0 and 8.8, respectively; p = 0.0064 and p = 0.014). [<superscript>18</superscript>F]FDG uptake was lowest in ER-positive/HER2-negative BC and highest in HER2-positive BC (geometric mean SUV<subscript>max</subscript> 6.8 and 10.0, respectively; p = 0.0058). Although [<superscript>18</superscript>F]FDG uptake was lower in invasive lobular carcinoma (n = 31) than invasive carcinoma NST (n = 146) (estimated geometric mean SUV<subscript>max</subscript> 5.8 versus 7.8; p = 0.014), the metastasis detection rate was similar. Conclusions: [<superscript>18</superscript>F]FDG-PET is a powerful tool to detect metastases, including invasive lobular carcinoma. Although BC histopathological characteristics are related to [<superscript>18</superscript>F]FDG uptake, [<superscript>18</superscript>F]FDG-PET and biopsy remain complementary in MBC staging (NCT01957332). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20754418
- Volume :
- 14
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Diagnostics (2075-4418)
- Publication Type :
- Academic Journal
- Accession number :
- 175653951
- Full Text :
- https://doi.org/10.3390/diagnostics14040416