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Comparison of the incidence of wound complications with preoperative and postoperative radiotherapy in patients with extremity soft tissue sarcoma resection: A meta‐analysis.
- Source :
- International Wound Journal; Feb2024, Vol. 21 Issue 2, p1-8, 8p
- Publication Year :
- 2024
-
Abstract
- We performed a meta‐analysis to compare the effect of preoperative and postoperative radiotherapy on wound complications after resection of extremity soft tissue sarcoma (ESTS). A comprehensive computerised search of the PubMed, Cochrane Library, Web of Science, EMBASE, China National Knowledge Infrastructure (CNKI), VIP, and Wanfang databases was conducted from their inception to August 2023 to identify studies comparing the effect of preoperative and postoperative radiotherapy on wound complications after ESTS resection. Two investigators independently screened the literature, extracted the data, and assessed the quality of the articles. The meta‐analysis was performed using RevMan 5.4 software. Nine studies with 1271 patients were included, with 631 and 640 patients in the preoperative and postoperative radiotherapy groups, respectively. The results showed that the incidence of postoperative wound complications after ESTS resection was significantly higher with preoperative radiotherapy than with postoperative radiotherapy (27.26% vs. 12.03%, odds ratio [OR]: 2.88, 95% confidence interval [CI]: 2.12–3.91, p < 0.001). However, the rate of local recurrence of ESTS was significantly lower with preoperative radiotherapy than with postoperative radiotherapy (8.75% vs. 14.81%, OR: 0.57, 95% CI: 0.36–0.91, p = 0.02), and the 3‐year overall survival was significantly higher in the preoperative radiotherapy group than in the postoperative radiotherapy group (82.24% vs. 70.04%, OR: 1.97, 95% CI: 1.05–3.71, p = 0.03). This pooled analysis suggests that although preoperative radiotherapy increases the rate of wound complications in ESTS compared with postoperative radiotherapy, it significantly reduces the rate of local recurrence after ESTS resection and improves the overall survival of patients. Owing to the limitations in the number and quality of the included studies, additional prospective cohort studies or randomised controlled trials are required to confirm these findings. [ABSTRACT FROM AUTHOR]
- Subjects :
- PREVENTION of surgical complications
PREOPERATIVE care
ONLINE information services
MEDICAL databases
META-analysis
MEDICAL information storage & retrieval systems
EXTREMITIES (Anatomy)
POSTOPERATIVE care
SURGICAL complications
DISEASE incidence
SURGERY
PATIENTS
CANCER relapse
SOFT tissue tumors
TREATMENT effectiveness
COMPARATIVE studies
CANCER patients
SURGICAL site
DESCRIPTIVE statistics
SURGICAL site infections
RADIOTHERAPY
MEDLINE
DATA analysis software
SARCOMA
OVERALL survival
EVALUATION
Subjects
Details
- Language :
- English
- ISSN :
- 17424801
- Volume :
- 21
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- International Wound Journal
- Publication Type :
- Academic Journal
- Accession number :
- 175670016
- Full Text :
- https://doi.org/10.1111/iwj.14441