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Efficacy of autologous platelet‐rich plasma combined with negative pressure sealing drainage in the treatment of patients with diabetic foot ulcer.
- Source :
- International Wound Journal; Feb2024, Vol. 21 Issue 2, p1-8, 8p
- Publication Year :
- 2024
-
Abstract
- This study systematically evaluates the efficacy of autologous platelet‐rich plasma (PRP) combined with negative pressure sealing drainage (NPSD) in the treatment of diabetic foot ulcers (DFU). A comprehensive computerized search was conducted in PubMed, Embase, Google Scholar, Cochrane Library, China National Knowledge Infrastructure, and Wanfang databases for randomized controlled trials (RCTs), from database inception to November 2023, on the treatment of DFU using autologous PRP combined with NPSD. Two researchers independently screened the literature, extracted data, and conducted quality assessments based on inclusion and exclusion criteria. Data analysis was performed using RevMan 5.4 software. A total of 17 RCTs involving 1325 DFU patients were included. The analysis revealed that the application of autologous PRP combined with NPSD in DFU patients significantly increased the ulcer healing rate (OR = 3.54, 95% CI: 2.71–4.62, p < 0.001) and the overall treatment efficacy rate (OR = 4.99, 95% CI: 3.46–7.19, p < 0.001), and significantly reduced the wound healing time (SMD = −2.05, 95% CI: −2.61 to −1.49, p < 0.001). This study indicates that the treatment of DFU with autologous PRP combined with NPSD accelerates wound healing, improves the overall treatment efficacy rate, and offers a new option for the management of DFU. [ABSTRACT FROM AUTHOR]
- Subjects :
- TREATMENT of diabetic foot
PLATELET-rich plasma
WOUND healing
ONLINE information services
MEDICAL databases
AUTOTRANSFUSION of blood
META-analysis
MEDICAL information storage & retrieval systems
CONFIDENCE intervals
SYSTEMATIC reviews
TREATMENT duration
NEGATIVE-pressure wound therapy
TREATMENT effectiveness
SEARCH engines
DESCRIPTIVE statistics
DISEASE duration
COMBINED modality therapy
MEDLINE
DATA analysis software
ODDS ratio
Subjects
Details
- Language :
- English
- ISSN :
- 17424801
- Volume :
- 21
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- International Wound Journal
- Publication Type :
- Academic Journal
- Accession number :
- 175670083
- Full Text :
- https://doi.org/10.1111/iwj.14700