Back to Search
Start Over
On the mechanism of action of arsenoplatins: arsenoplatin-1 binding to a B-DNA dodecamer.
- Source :
- Dalton Transactions: An International Journal of Inorganic Chemistry; 2/28/2024, Vol. 53 Issue 8, p3476-3483, 8p
- Publication Year :
- 2024
-
Abstract
- The reaction of Pt-based anticancer agents with arsenic trioxide affords robust complexes known as arsenoplatins. The prototype of this family of anticancer compounds is arsenoplatin-1 (AP-1) that contains an As(OH)<subscript>2</subscript> fragment linked to a Pt(II) moiety derived from cisplatin. Crystallographic and spectrometric studies of AP-1 binding to a B-DNA double helix dodecamer are presented here, in comparison with cisplatin and transplatin. Results reveal that AP-1, cisplatin and transplatin react differently with the DNA model system. Notably, in the AP-1/DNA systems, the Pt–As bond can break down with time and As-containing fragments can be released. These results have implications for the understanding of the mechanism of action of arsenoplatins. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANTINEOPLASTIC agents
CISPLATIN
Subjects
Details
- Language :
- English
- ISSN :
- 14779226
- Volume :
- 53
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Dalton Transactions: An International Journal of Inorganic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 175728561
- Full Text :
- https://doi.org/10.1039/d3dt04302a