Findings in Zika Virus Reported from Beijing Institute of Pharmacology and Toxicology (Paper Investigation of Novel 5'-amino Adenosine Derivatives With Potential Anti-zika Virus Activity).

New research from the Beijing Institute of Pharmacology and Toxicology in China has identified a potential anti-Zika virus compound called XSJ2-46. The compound demonstrated potent in vitro activity against the Zika virus without requiring chemical phosphorylation and showed favorable pharmacokinetic and acute toxicity profiles. XSJ2-46 acted at the replication stage of the viral infection cycle and inhibited RNA-dependent RNA polymerases. In animal models, XSJ2-46 enhanced survival protection and decreased serum levels of Zika virus RNA. This research highlights the potential of utilizing the 5'-amino NI structure skeleton for developing antiviral compounds. [Extracted from the article]