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A comparison of diagnostic performance of word-list and story recall tests for biomarker-determined Alzheimer's disease.

A comparison of diagnostic performance of word-list and story recall tests for biomarker-determined Alzheimer's disease.

Authors :
Bruno, Davide
Jauregi Zinkunegi, Ainara
Kollmorgen, Gwendlyn
Carboni, Margherita
Wild, Norbert
Carlsson, Cynthia
Bendlin, Barbara
Okonkwo, Ozioma
Chin, Nathaniel
Hermann, Bruce P.
Asthana, Sanjay
Blennow, Kaj
Langhough, Rebecca
Johnson, Sterling C.
Pomara, Nunzio
Zetterberg, Henrik
Mueller, Kimberly D.
Source :
Journal of Clinical & Experimental Neuropsychology; Oct2023, Vol. 45 Issue 8, p763-769, 7p
Publication Year :
2023

Abstract

Wordlist and story recall tests are routinely employed in clinical practice for dementia diagnosis. In this study, our aim was to establish how well-standard clinical metrics compared to process scores derived from wordlist and story recall tests in predicting biomarker determined Alzheimer's disease, as defined by CSF ptau/Aβ42 ratio. Data from 295 participants (mean age = 65 ± 9.) were drawn from the University of Wisconsin – Madison Alzheimer's Disease Research Center (ADRC) and Wisconsin Registry for Alzheimer's Prevention (WRAP). Rey's Auditory Verbal Learning Test (AVLT; wordlist) and Logical Memory Test (LMT; story) data were used. Bayesian linear regression analyses were carried out with CSF ptau/Aβ42 ratio as outcome. Sensitivity analyses were carried out with logistic regressions to assess diagnosticity. LMT generally outperformed AVLT. Notably, the best predictors were primacy ratio, a process score indexing loss of information learned early during test administration, and recency ratio, which tracks loss of recently learned information. Sensitivity analyses confirmed this conclusion. Our study shows that story recall tests may be better than wordlist tests for detection of dementia, especially when employing process scores alongside conventional clinical scores. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13803395
Volume :
45
Issue :
8
Database :
Complementary Index
Journal :
Journal of Clinical & Experimental Neuropsychology
Publication Type :
Academic Journal
Accession number :
175795667
Full Text :
https://doi.org/10.1080/13803395.2023.2240060