Back to Search
Start Over
Adverse outcomes in subsequent pregnancies in women with history of recurrent spontaneous abortion: A meta‐analysis.
- Source :
- Journal of Obstetrics & Gynaecology Research; Mar2024, Vol. 50 Issue 3, p281-297, 17p
- Publication Year :
- 2024
-
Abstract
- Objective: This study aimed to investigate the association between a history of recurrent spontaneous abortion (RSA) and adverse outcomes in women with spontaneous conception. Methods: A search strategy from the inception to March 3, 2023 was run in PubMed, Embase, Cochrane Library, and Web of Science databases. The odds ratio (OR), and the 95% confidence interval (CI) or point estimation were used as the evaluation indexes. Each outcome measure tested was assessed for heterogeneity using the Cochran Q test. Sensitivity analyses were performed to test the credibility of the meta‐analysis results. Results: Fifteen studies involving 1 475 389 pregnant women were included. A history of RSA was associated with gestational diabetes (OR: 2.21, 95% CI: 1.70–2.87, p < 0.001), preeclampsia (OR: 2.06, 95% CI: 1.49–2.86, p < 0.001), placenta previa (OR: 1.82, 95% CI: 1.09–3.02, p = 0.021), placental abruption (OR: 1.67, 95% CI: 1.36–2.06, p < 0.001), miscarriage (OR: 6.37, 95% CI: 3.83–10.57, p < 0.001), preterm birth (OR: 1.80, 95% CI: 1.36–2.37, p < 0.001), cesarean section (OR: 1.47, 95% CI: (1.13–1.91, p = 0.004), perinatal death (OR: 2.24, 95% CI: 1.39–3.60, p = 0.001), and neonatal intensive care unit admission (OR: 1.39, 95% CI: 1.01–1.92, p = 0.047). However, the associations of a history of RSA with gestational hypertension, small for gestational age, fetal anomalies, fetal growth restriction, and postpartum hemorrhage were not observed. Conclusion: This meta‐analysis indicates a history of RSA was associated with increased risks of several adverse outcomes in pregnant women with spontaneous conception. [ABSTRACT FROM AUTHOR]
- Subjects :
- ONLINE information services
MEDICAL databases
META-analysis
MEDICAL information storage & retrieval systems
CONFIDENCE intervals
NEONATAL intensive care
MISCARRIAGE
SYSTEMATIC reviews
ABRUPTIO placentae
NEONATAL intensive care units
PREGNANCY outcomes
PREECLAMPSIA
PERINATAL death
PLACENTA praevia
DESCRIPTIVE statistics
RESEARCH funding
MEDLINE
ODDS ratio
GESTATIONAL diabetes
WOMEN'S health
DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 13418076
- Volume :
- 50
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Obstetrics & Gynaecology Research
- Publication Type :
- Academic Journal
- Accession number :
- 175799852
- Full Text :
- https://doi.org/10.1111/jog.15848