Colchicine to prevent sympathetic denervation after acute myocardial infarction: the COLD-MI trial.

The article discusses the results of the COLD-MI trial, which aimed to explore the impact of colchicine on myocardial denervation in patients who had experienced an acute myocardial infarction (AMI). The study found that colchicine reduced myocardial denervation in both the infarcted and non-infarcted zones of the heart. However, there were no significant effects on other parameters such as necrosis size or left ventricular ejection fraction. The study also noted an increase in gastrointestinal side effects with colchicine use. Overall, the findings suggest that colchicine may have a positive effect on reducing cardiac denervation in patients after AMI. [Extracted from the article]