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CD8+ T-cell response against MUC1-derived peptides in gastrointestinal cancer survivors.
- Source :
- Cancer Immunology, Immunotherapy; Aug2005, Vol. 54 Issue 8, p750-758, 9p
- Publication Year :
- 2005
-
Abstract
- The tumor-associated antigens CEA, MUC1 and Her2/neu are broadly expressed in gastrointestinal tumors, and are attractive candidates for targeting by T-cell-based immunotherapy. However, little is known about the natural cytotoxic T-cell response of patients suffering from colorectal or gastric carcinoma against these three as well as other antigens. Using a quantitative reverse transcription-polymerase chain reaction-based assay for IFN-γ, we analyzed the CD8<superscript>+</superscript> T-cell repertoire present in the blood of HLA-A2<superscript>+</superscript> gastrointestinal tumor survivors against five known epitopes derived from CEA, MUC1 and Her2/neu. The results show that most of the patients (16 from 22 tested) have detectable, peripheral CD8<superscript>+</superscript> T cells directed against at least one of these three proteins. Interestingly, the majority of these patients reacts to the two MUC1-derived HLA-A*0201 epitopes tested (14 from 16), demonstrating that this protein represents one dominant target for CD8<superscript>+</superscript> T cells in gastrointestinal cancer. [ABSTRACT FROM AUTHOR]
- Subjects :
- T cells
LYMPHOCYTES
PEPTIDES
PROTEINS
GASTROINTESTINAL cancer
CANCER patients
Subjects
Details
- Language :
- English
- ISSN :
- 03407004
- Volume :
- 54
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Cancer Immunology, Immunotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 17580248
- Full Text :
- https://doi.org/10.1007/s00262-004-0640-7