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Letermovir Effectively Prevents Cytomegalovirus Infection in Patients with Aplastic Anemia After Hematopoietic Stem Cell Transplantation: A Real-World Retrospective Cohort Study.
- Source :
- Infectious Diseases & Therapy; Feb2024, Vol. 13 Issue 2, p345-359, 15p
- Publication Year :
- 2024
-
Abstract
- Introduction: In this single-center retrospective cohort study, we investigated the efficacy of letermovir in preventing Cytomegalovirus (CMV) infection in patients with aplastic anemia (AA) who have undergone allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods: Based on whether or not letermovir was used for preventing CMV infection, the patients were categorized into two groups: letermovir and control groups. The overall survival (OS) rate and cumulative incidence of CMV infection during the first 100 days after allo-HSCT were evaluated. The study included 21 matched pairs of patients, identified through propensity score matching analysis, to compare CMV infection rates, treatment efficacy, and regression. Results: The incidence of CMV infection within 100 days after transplantation was significantly lower in the letermovir group than in the control group (26.5 vs. 77.4%, respectively; P < 0.001), among a total of 87 patients who underwent the transplant. In the matched cohort of 21 patients with AA, the letermovir group also showed a significantly reduced cumulative incidence of CMV infection (14.3 vs. 90.5% in the control group; P < 0.001). Compared to the control group, patients with CMV infection in the letermovir group had lower CMV-DNA load and a shorter clearance time. However, there was no significant difference in OS between both groups (P = 0.34). Conclusions: Letermovir effectively prevents CMV infection in allo-HSCT recipients with AA and demonstrates a high safety profile. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 21938229
- Volume :
- 13
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Infectious Diseases & Therapy
- Publication Type :
- Academic Journal
- Accession number :
- 175831490
- Full Text :
- https://doi.org/10.1007/s40121-024-00917-2