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Clinical Efficacy of Topical Nasal Pomegranate Fruit Extract for Chronic Rhinitis and Chronic Rhinosinusitis.
- Source :
- ENT: Ear, Nose & Throat Journal; Mar2024, Vol. 103 Issue 3, pNP148-NP157, 10p
- Publication Year :
- 2024
-
Abstract
- Objective: To evaluate the clinical efficacy of topical nasal Pomegranate Fruit Extract (PFE) for Chronic Rhinitis (CR), Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP), and Chronic Rhinosinusitis without Nasal Polyposis (CRSsNP). Methods: Prospective, double-blinded, randomized study including 111 consecutive patients, between April 2012 and January 2017, afflicted by CRSwNP, CRSsNP, and CR. Patients from each group were randomly assigned to either PFE treatment or placebo twice daily for 30 days. Therapeutic efficacy was assessed by Ear Nose and Throat, blood and tomographic examinations, and the SNOT-20 questionnaire. Results: CR patients treated with PFE suffered significantly less from thick nasal discharge, difficulty falling asleep, reduced productivity, reduced concentration, and sadness (P =.004, P =.02, P =.03, P =.007 and P =.02, respectively). Conclusions: Topical nasal PFE was found to have some benefits for CR patients, however, not for CRS with or without Nasal Polyposis. [ABSTRACT FROM AUTHOR]
- Subjects :
- PHYTOTHERAPY
CUTANEOUS therapeutics
ENDOSCOPES
INTRANASAL administration
PLACEBOS
LABOR productivity
SADNESS
BLIND experiment
STATISTICAL sampling
COMPUTED tomography
QUESTIONNAIRES
SINUSITIS
TREATMENT effectiveness
RANDOMIZED controlled trials
DESCRIPTIVE statistics
RHINITIS
PLANT extracts
NASAL polyps
LONGITUDINAL method
ATTENTION
POMEGRANATE
DRUG efficacy
DATA analysis software
SLEEP disorders
EVALUATION
Subjects
Details
- Language :
- English
- ISSN :
- 01455613
- Volume :
- 103
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- ENT: Ear, Nose & Throat Journal
- Publication Type :
- Academic Journal
- Accession number :
- 175872004
- Full Text :
- https://doi.org/10.1177/01455613211044224