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Bisphenol A regulates bladder cells responses via control of G2/M‐phase cell cycle, apoptotic signaling, MAPK pathway, and transcription factor‐associated MMP modulation.

Authors :
Song, Jun‐Hui
Hwang, Byungdoo
Park, Solbi
Kim, Soobin
Kim, Dong‐Ho
Choi, Yung Hyun
Kim, Wun‐Jae
Moon, Sung‐Kwon
Source :
Journal of Biochemical & Molecular Toxicology; Mar2024, Vol. 38 Issue 3, p1-13, 13p
Publication Year :
2024

Abstract

Bisphenol A (BPA), an exogenous endocrine‐disrupting chemical, is widely used to produce polycarbonate plastics. The widely used BPA has been detected in human urine samples, raising public anxiety about the detrimental effects of BPA on the bladder. In this study, we explored regulatory mechanisms for the adverse effects of BPA in human bladder BdFC and T24 cells. BPA induced extrinsic and intrinsic apoptosis and G2/M cell cycle arrest caused by the ATM‐CHK1/CHK2‐CDC25c‐CDC2 signaling, which ultimately inhibited the growth of human bladder cells. We also found that BPA decreased the binding activity of AP‐1 and NF‐κB transcription factors in human bladder cells, which inhibited migration and invasion through matrix metallopeptidase‐2 and ‐9 inactivation. Phosphorylation of MAPKs was implicated with BPA‐mediated detrimental effects in human bladder cells. Collectively, our results provide a novel explanation for the underlying molecular mechanisms that BPA induces cytotoxicity in human bladder cells. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10956670
Volume :
38
Issue :
3
Database :
Complementary Index
Journal :
Journal of Biochemical & Molecular Toxicology
Publication Type :
Academic Journal
Accession number :
176011809
Full Text :
https://doi.org/10.1002/jbt.23662