SIEGA the integrated genomic surveillance system of Andalusia, a One Health regional resource connected with the clinic.

The article discusses the importance of the One Health approach in addressing emerging zoonotic diseases and antibiotic resistance concerns. It highlights the SIEGA system, a collaborative tool that monitors infectious diseases across different domains and fosters a comprehensive understanding of disease dynamics and risk factors. The SIEGA system utilizes raw whole-genome sequencing and open software to detect antimicrobial resistances and virulence genes. It has successfully accumulated a collection of over 1900 bacterial genomes, showcasing its potential in monitoring pathogen transmission, resistance patterns, and virulence factors. The integration of health data from humans, animals, and the environment, coupled with advanced genomics, underscores the importance of a holistic One Health approach in mitigating health threats. [Extracted from the article]