Findings in Drug Research Reported from Bundeswehr Institute of Pharmacology and Toxicology (Ache Reactivation In Precision-cut Lung Slices Following Organophosphorus Compound Poisoning).

A recent study conducted at the Bundeswehr Institute of Pharmacology and Toxicology in Munich, Germany, has found that precision-cut lung slices (PCLS) can be used as a model to analyze the activity of acetylcholinesterase (AChE) and its effects after exposure to organophosphorus (OP) compounds. The study investigated the reactivation of AChE in PCLS exposed to three different OP nerve agents and treated with three reactivators. The results showed that the reactivators had varying effects on AChE reactivation, with the best results observed for PCLS exposed to sarin (GB). The findings suggest the potential for future improvements in the treatment of OP-exposed victims. [Extracted from the article]