Combination pharmacological therapy targeting multiple mechanisms of sleep apnoea: a randomised controlled cross-over trial.

This document summarizes a study on the effectiveness of different interventions for obstructive sleep apnea (OSA). The study found that combining acetazolamide with atomoxetine-oxybutynin did not provide any additional improvement in OSA severity compared to either agent alone. Both interventions were effective in reducing the apnea-hypopnea index (AHI). The study suggests that longer-term trials of these interventions in the appropriate populations are warranted. The document also discusses the role of compensatory muscle force in preventing OSA and potential pathways for attenuating OSA using different interventions. [Extracted from the article]