Amoeboid cells undergo durotaxis with soft end polarized NMIIA (Updated March 7, 2024).

According to a preprint abstract from biorxiv.org, researchers have found that amoeboid cells, specifically T cells and neutrophils, can migrate towards stiff substrates in a process called durotaxis. This migration is believed to play a role in development, wound healing, and cancer. The researchers also discovered that the polarization of non-muscle myosin IIA (NMIIA) towards the soft side of the matrix is involved in this process. The study suggests that these findings could have implications for immune surveillance and the migration of cancer cells in mechanically heterogeneous environments. However, it is important to note that this preprint has not yet undergone peer review. [Extracted from the article]