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Age-related variation in coagulation factors in non-valvular atrial fibrillation patients receiving direct oral anticoagulants.

Authors :
Kumano, Osamu
Suzuki, Shinya
Yamazaki, Masako
An, Yoshimori
Yasaka, Masahiro
Ieko, Masahiro
Sasaki, Mayumi
Matsuda, Kazumi
Kitagawa, Kazuo
Shiga, Tsuyoshi
Miura, Hitomi
Tamura, Takako
Kondo, Maki
Akao, Masaharu
Kamata, Chika
Masuda, Yoshinobu
Mitsuhashi, Tomoko
Tomoda, Masanori
Tomoyose, Ryuuta
Nishiura, Akihiko
Source :
International Journal of Hematology; Apr2024, Vol. 119 Issue 4, p407-415, 9p
Publication Year :
2024

Abstract

Age is a significant risk factor for ischemic stroke. However, the influence of aging on coagulation parameters in non-valvular atrial fibrillation (NVAF) patients treated with direct oral anticoagulants (DOACs) remains unclear. A total of 775 samples were collected from 224 NVAF patients receiving apixaban, edoxaban or rivaroxaban. The samples were categorized into three age groups: (i) ≤ 64 years, (ii) 65–74 years, and (iii) ≥ 75 years (apixaban: N = 48, 108, 119; edoxaban: N = 63, 68, 126; rivaroxaban: N = 115, 90, 38, respectively). Coagulation parameters including fibrinogen (Fbg), factor II, factor V, factor VII, factor X, and D-dimer, were compared between the three age groups for each drug. The slopes in the correlation between drug concentrations and modified diluted prothrombin time (mdPT) were also assessed. Fbg and factor V increased with age, while factor II and factor X decreased. Factor VII and D-dimer showed no significant differences across age categories. The slope in response to drug concentrations was similar between the age groups. In NVAF patients treated with apixaban, edoxaban and rivaroxaban, some coagulation parameters exhibited age-related variation. However, the response of mdPT to drug concentration was consistent across age categories. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09255710
Volume :
119
Issue :
4
Database :
Complementary Index
Journal :
International Journal of Hematology
Publication Type :
Academic Journal
Accession number :
176221539
Full Text :
https://doi.org/10.1007/s12185-024-03712-4